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Bicarbonate: Definition, Formula and More

Of the three buffer systems, the bicarbonate buffer system is arguably the most important as it is the only one that is coupled to the respiratory system.

Carbonic acid (H2CO3) is a weak acid (pKa1=6.3, pKa2=10.3), and is formed when carbon dioxide combines with water in a reaction catalyzed by the enzyme carbonic anhydrase.

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