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Definition of Gamma Globulin


Gammaglobulin is a somewhat ambiguous term that still remains in common usage despite attempts to substitute ‘immunoglobulin’ in its place. In general terms, ‘gammaglobulin’ is a class of plasma proteins composed almost entirely of immunoglobulins (Igs), the proteins that function as antibodies. These plasma proteins are characterized by a very slow electrophoretic mobility in an alkaline buffer.


‘Gammaglobulin’ is also used as a clinical name, given to the immunoglobulin concentrates that are given parenterally to humans for immunoprophylaxis against infectious disease, or for passive antibody replacement in humoral immunodeficiency disease.


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